Blar i NILU Brage på forfatter "Gábelová, Alena"
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Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models
Buociková, Verona; Longhin, Eleonora Marta; Pilalis, Eleftherios; Mastrokalou, Chara; Miklíková, Svetlana; Cihova, Marina; Poturnayova, Alexandra; Mackova, Katarina; Bábelová, Andrea; Trnkova, Lenka; El Yamani, Naouale; Zheng, Congying; Rios-Mondragon, Ivan; Labudova, Martina; Csaderova, Lucia; Kuracinova, Kristina Mikus; Makovicky, Peter; Kučerová, Lucia; Matuskova, Miroslava; Cimpan, Mihaela-Roxana; Dusinska, Maria; Babal, Pavel; Chatziioannou, Aristotelis; Gábelová, Alena; Rundén-Pran, Elise; Smolkova, Bozena (Peer reviewed; Journal article, 2022)Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ... -
Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression
Buociková, Verona; Tyciakova, Sylvia; Pilalis, Eleftherios; Mastrokalou, Chara; Urbanova, Maria; Matuskova, Miroslava; Demkova, Lucia; Medova, Veronika; Longhin, Eleonora Marta; Rundén-Pran, Elise; Dusinska, Maria; Rios Mondragon, Ivan; Cimpan, Mihaela-Roxana; Gábelová, Alena; Soltysova, Andrea; Smolkova, Bozena; Chatziioannou, Aristotelis (Peer reviewed; Journal article, 2022)Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising ... -
Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives
Buociková, Verona; Rios-Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
Epigenetics in breast cancer therapy—New strategies and future nanomedicine perspectives
Buociková, Verona; Rios Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results
Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa; Koppen, Gudrun; Bonassi, Stefano; Milic, Mirta; Gajski, Goran; Costa, Solange; Teixeira, João Paulo; Pereira, Cristiana Costa; Dusinska, Maria; Godschalk, Roger; Brunborg, Gunnar; Gutzkow, Kristine Bjerve; Giovannelli, Lisa; Cooke, Marcus S.; Richling, Elke; Laffon, Blanca; Valdiglesias, Vanessa; Basaran, Nursen; Del Bo, Cristian; Zegura, Bojana; Novak, Matjaz; Stopper, Helga; Vodicka, Pavel; Vodenkova, Sona; de Andrade, Vanessa Moraes; Srámková, Monika; Gábelová, Alena; Collins, Andrew Richard; Langie, Sabine A.S. (Peer reviewed; Journal article, 2020)The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. ... -
Nanomedicine and epigenome. Possible health risks.
Smolkova, Bozena; Dusinska, Maria; Gábelová, Alena (Journal article; Peer reviewed, 2017) -
Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation
Dubaj, Tibor; Kozics, Katarina; Srámková, Monika; Manova, Alena; Bastus, Neus G.; Moriones, Oscar H.; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise; Puntes, Victor; Nelson, Andrew; Gábelová, Alena; Simon, Peter (Peer reviewed; Journal article, 2022)Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies ...